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VOTRIENT^® (pazopanib) tablets

Important Safety Information, including Boxed WARNING:

Before taking VOTRIENT, tell your health care provider if you have or had liver problems. Some people may develop liver damage while taking VOTRIENT. VOTRIENT can cause serious liver problems, including death. Your health care provider will do blood tests to check your liver before you start and while you take VOTRIENT. Tell your health care provider right away if you have yellow eyes or skin, dark urine, tiredness, nausea or vomiting, loss of appetite, pain in the right upper side of your stomach area, or if you bruise easily. Your health care provider may need to prescribe a lower dose of VOTRIENT for you or tell you to stop taking VOTRIENT if you develop liver problems during treatment.

Approved Use:

VOTRIENT^® (pazopanib) tablets is a prescription medicine used to treat people with advanced soft tissue sarcoma (STS) who have received chemotherapy in the past.

It is not known if VOTRIENT is effective in treating certain soft tissue sarcomas or certain gastrointestinal tumors.

It is not known if VOTRIENT is safe and effective in children under 18 years of age.

Important Safety Information:

VOTRIENT may cause irregular or fast heartbeat or fainting.
VOTRIENT may cause heart failure, a condition where your heart does not pump as well as it should and which may result in shortness of breath.
Heart attack and stroke can happen with VOTRIENT and may cause death. Tell your health care provider if you have heart problems. Call your health care provider right away if you have chest pain or pressure, pain in your arms, back, neck, or jaw, shortness of breath, numbness or weakness on one side of your body, trouble talking, headache, or dizziness.
VOTRIENT may cause blood clots, which may form in a vein, especially in your legs. Pieces of a blood clot may travel to your lungs. This may be life threatening and cause death. Call your health care provider right away if you have new chest pain, trouble breathing or sudden shortness of breath, leg pain, and swelling of the arms and hands, or legs and feet, a cool or pale arm or leg.
Thrombotic microangiopathy (TMA), including thrombotic thrombocytopenia purpura and hemolytic uremic syndrome, is a condition involving blood clots that can happen while taking VOTRIENT. TMA is accompanied by a decrease in red blood cells and cells that are involved in clotting. TMA may harm organs such as the brain and kidneys.
VOTRIENT may cause bleeding problems, which may be severe and cause death. Tell your health care provider before taking VOTRIENT if you have a history of abnormal bleeding. If you experience unusual bleeding, bruising, or wounds that do not heal, call your health care provider right away.
VOTRIENT may cause a tear (called a perforation) in the stomach or intestinal wall. Fatal perforations have occurred. VOTRIENT may also cause an abnormal connection between 2 parts of your gastrointestinal tract (called a fistula). Call your health care provider if you experience pain or swelling in the stomach area, vomiting blood, or black sticky stools.
VOTRIENT may cause lung problems that may lead to death. Tell your health care provider right away if you develop a cough that will not go away or have shortness of breath.
Reversible posterior leukoencephalopathy syndrome is a condition that can happen while taking VOTRIENT that may cause death. Symptoms may include headaches, seizures, lack of energy, confusion, high blood pressure, loss of speech, blindness or changes in vision, and problems thinking.
High blood pressure can happen with VOTRIENT, including a sudden and severe rise in blood pressure, which may be life threatening. These blood pressure increases usually happen in the first several months of treatment. Blood pressure should be well controlled before starting VOTRIENT. Your health care provider should test your blood pressure within 1 week of starting treatment with VOTRIENT and should check it often during treatment. Get medical help right away if you have symptoms of a severe increase in blood pressure, such as severe chest pain, severe headache, blurred vision, confusion, nausea and vomiting, severe anxiety, shortness of breath, or seizures, or if you pass out (become unconscious).
VOTRIENT may cause thyroid problems. Your health care provider should test your thyroid function during treatment with VOTRIENT.
VOTRIENT may affect wound healing. Tell your health care provider if you had recent surgery (within the last 7 days) or are going to have surgery.
VOTRIENT may cause you to have too much protein in your urine. Your health care provider will check you for this problem. If there is too much protein in your urine, your health care provider may tell you to stop taking VOTRIENT.
Serious infections can happen with VOTRIENT and can cause death. Call your health care provider if you experience fever; cold symptoms, such as runny nose or a sore throat that does not go away; flu symptoms, such as cough, feeling tired, and body aches; pain when urinating; or cuts, scrapes, or wounds that are red, warm, swollen, or painful.
When used in combination with some other anticancer therapies, VOTRIENT has caused increased toxicity and even death. Tell your health care provider about all of the medicines you are taking, including other anticancer therapies.
FEMALES OF REPRODUCTIVE/CHILDBEARING POTENTIAL. VOTRIENT can harm your unborn baby (cause birth defects or potential loss of pregnancy). You should not become pregnant while you are taking VOTRIENT. You should use effective birth control during treatment with VOTRIENT and for at least 2 weeks after your final dose of VOTRIENT. Talk to your health care provider about the types of birth control that may be right for you during this time.
MALES OF REPRODUCTIVE POTENTIAL. Talk to your doctor if you are a male, even if you have had a vasectomy, and you are with a sexual partner who is pregnant, thinks that she may be pregnant, or who could become pregnant (including those who use other forms of birth control). You should use condoms during sexual intercourse during treatment with VOTRIENT and for at least 2 weeks after your last dose with VOTRIENT.
BREASTFEEDING. It is not known if VOTRIENT passes into your breast milk. Do not breastfeed during treatment with VOTRIENT and for 2 weeks after the final dose.
A collapsed lung can happen with VOTRIENT (called pneumothorax). This may cause shortness of breath. Call your health care provider right away if you experience shortness of breath.

The most common side effects in people who take VOTRIENT include:

Diarrhea
High blood pressure
Change in hair color
Nausea or vomiting
Loss of appetite

Other common side effects in people with advanced soft tissue sarcoma who take VOTRIENT include:

Feeling tired
Decreased weight
Tumor, muscle, or bone pain
Stomach pain
Headache
Taste changes
Trouble breathing
Change in skin color

Tell your health care provider right away if you have any side effects.

VOTRIENT may affect the way other medicines work and other medicines may affect how VOTRIENT works. Tell your health care provider about all the medicines you take, including prescription and nonprescription medicines, and herbal and dietary supplements.

Do not eat grapefruit or drink grapefruit juice during treatment with VOTRIENT because it may affect how VOTRIENT works.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see accompanying full Prescribing Information, including Boxed WARNING, and Medication Guide.

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Prescribing Info including Med Guide

Patient Support Line 1-888-669-6682
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Important Safety Information, including Boxed WARNING:

Approved Use:

VOTRIENT^® (pazopanib) tablets is a prescription medicine used to treat people with advanced soft tissue sarcoma (STS) who have received chemotherapy in the past.

It is not known if VOTRIENT is effective in treating certain soft tissue sarcomas or certain gastrointestinal tumors.

It is not kn...

Important Safety Information, including Boxed WARNING:

Approved Use:

VOTRIENT^® (pazopanib) tablets is a prescription medicine used to treat people with advanced soft tissue sarcoma (STS) who have received chemotherapy in the past.

It is not known if VOTRIENT is effective in treating certain soft tissue sarcomas or certain gastrointestinal tumors.

It is not known if VOTRIENT is safe and effective in children under 18 years of age.

Important Safety Information:

VOTRIENT may cause irregular or fast heartbeat or fainting.
VOTRIENT may cause heart failure, a condition where your heart does not pump as well as it should and which may result in shortness of breath.
Heart attack and stroke can happen with VOTRIENT and may cause death. Tell your health care provider if you have heart problems. Call your health care provider right away if you have chest pain or pressure, pain in your arms, back, neck, or jaw, shortness of breath, numbness or weakness on one side of your body, trouble talking, headache, or dizziness.
VOTRIENT may cause blood clots, which may form in a vein, especially in your legs. Pieces of a blood clot may travel to your lungs. This may be life threatening and cause death. Call your health care provider right away if you have new chest pain, trouble breathing or sudden shortness of breath, leg pain, and swelling of the arms and hands, or legs and feet, a cool or pale arm or leg.
Thrombotic microangiopathy (TMA), including thrombotic thrombocytopenia purpura and hemolytic uremic syndrome, is a condition involving blood clots that can happen while taking VOTRIENT. TMA is accompanied by a decrease in red blood cells and cells that are involved in clotting. TMA may harm organs such as the brain and kidneys.
VOTRIENT may cause bleeding problems, which may be severe and cause death. Tell your health care provider before taking VOTRIENT if you have a history of abnormal bleeding. If you experience unusual bleeding, bruising, or wounds that do not heal, call your health care provider right away.
VOTRIENT may cause a tear (called a perforation) in the stomach or intestinal wall. Fatal perforations have occurred. VOTRIENT may also cause an abnormal connection between 2 parts of your gastrointestinal tract (called a fistula). Call your health care provider if you experience pain or swelling in the stomach area, vomiting blood, or black sticky stools.
VOTRIENT may cause lung problems that may lead to death. Tell your health care provider right away if you develop a cough that will not go away or have shortness of breath.
Reversible posterior leukoencephalopathy syndrome is a condition that can happen while taking VOTRIENT that may cause death. Symptoms may include headaches, seizures, lack of energy, confusion, high blood pressure, loss of speech, blindness or changes in vision, and problems thinking.
High blood pressure can happen with VOTRIENT, including a sudden and severe rise in blood pressure, which may be life threatening. These blood pressure increases usually happen in the first several months of treatment. Blood pressure should be well controlled before starting VOTRIENT. Your health care provider should test your blood pressure within 1 week of starting treatment with VOTRIENT and should check it often during treatment. Get medical help right away if you have symptoms of a severe increase in blood pressure, such as severe chest pain, severe headache, blurred vision, confusion, nausea and vomiting, severe anxiety, shortness of breath, or seizures, or if you pass out (become unconscious).
VOTRIENT may cause thyroid problems. Your health care provider should test your thyroid function during treatment with VOTRIENT.
VOTRIENT may affect wound healing. Tell your health care provider if you had recent surgery (within the last 7 days) or are going to have surgery.
VOTRIENT may cause you to have too much protein in your urine. Your health care provider will check you for this problem. If there is too much protein in your urine, your health care provider may tell you to stop taking VOTRIENT.
Serious infections can happen with VOTRIENT and can cause death. Call your health care provider if you experience fever; cold symptoms, such as runny nose or a sore throat that does not go away; flu symptoms, such as cough, feeling tired, and body aches; pain when urinating; or cuts, scrapes, or wounds that are red, warm, swollen, or painful.
When used in combination with some other anticancer therapies, VOTRIENT has caused increased toxicity and even death. Tell your health care provider about all of the medicines you are taking, including other anticancer therapies.
FEMALES OF REPRODUCTIVE/CHILDBEARING POTENTIAL. VOTRIENT can harm your unborn baby (cause birth defects or potential loss of pregnancy). You should not become pregnant while you are taking VOTRIENT. You should use effective birth control during treatment with VOTRIENT and for at least 2 weeks after your final dose of VOTRIENT. Talk to your health care provider about the types of birth control that may be right for you during this time.
MALES OF REPRODUCTIVE POTENTIAL. Talk to your doctor if you are a male, even if you have had a vasectomy, and you are with a sexual partner who is pregnant, thinks that she may be pregnant, or who could become pregnant (including those who use other forms of birth control). You should use condoms during sexual intercourse during treatment with VOTRIENT and for at least 2 weeks after your last dose with VOTRIENT.
BREASTFEEDING. It is not known if VOTRIENT passes into your breast milk. Do not breastfeed during treatment with VOTRIENT and for 2 weeks after the final dose.
A collapsed lung can happen with VOTRIENT (called pneumothorax). This may cause shortness of breath. Call your health care provider right away if you experience shortness of breath.

The most common side effects in people who take VOTRIENT include:

Diarrhea
High blood pressure
Change in hair color
Nausea or vomiting
Loss of appetite

Other common side effects in people with advanced soft tissue sarcoma who take VOTRIENT include:

Feeling tired
Decreased weight
Tumor, muscle, or bone pain
Stomach pain
Headache
Taste changes
Trouble breathing
Change in skin color

Tell your health care provider right away if you have any side effects.

Do not eat grapefruit or drink grapefruit juice during treatment with VOTRIENT because it may affect how VOTRIENT works.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see accompanying full Prescribing Information, including Boxed WARNING, and Medication Guide.

Back To Site

Create a circle of support

You may feel powerless over what’s happening in your body. It may help to talk with your health care provider about emotions you may be experiencing. It may also be helpful to create a circle of support and surround yourself with people who care about you and can help you cope with your condition.

Your circle of support can include:

Your health care provider or other members of your cancer team
Friends
Family members
A support group
Other people who have cancer

Find a support group

You may feel all alone if you are the only person you know with advanced soft tissue sarcoma. When you’re feeling down and alone, it may help to talk to a friend, family member, or a patient support group. Click here for a list of patient support groups.

Ask for help

Being reliant upon others for support can sometimes make you feel like you’ve lost your independence, but don’t be afraid to ask for help when you need it.

Communicating with your cancer care team

Many different people may be working with you along the way and become part of your cancer care team. To give you the help and support you need, your cancer care team members need to know how you are doing. It’s important that you ask how and when you can reach them between appointments in case you have any questions.

Always let your health care providers know:

If you are having symptoms or potential side effects
The exact symptoms you have, when they happen, and how long they last
What, if anything, makes the symptoms better or worse

Tips for caregivers: sharing your strength

Caring for someone with cancer is an important responsibility. It takes energy and dedicated effort each day. You may:

Provide encouragement and support
Help keep other family members informed about what’s going on
Help with household chores and cooking meals
Take care of medical insurance paperwork and pay bills
Help with organizing medicines, going to doctor appointments, or meeting with the cancer care team

Being a care partner requires a lot of energy and can be tiring. You need to take time to care for yourself. Your own needs are important, too. Consider these ideas to help you cope:

Spend time with people who love and support you
Join a social activity
Practice relaxation methods, such as yoga or meditation
Eat well-balanced, healthy meals
Try to fit in at least 30 minutes of exercise most days of the week. Be sure to talk with your doctor before starting any exercise program
At least once a week, set aside some time to do something you enjoy

Support and resources

The following is a list of some organizations that offer information and support for people living with cancer and their care partners. You may find other online resources useful as well, such as patient support groups specific to advanced soft tissue sarcoma. Novartis is neither affiliated with nor endorses any of these organizations and does not control, and is not responsible for, the information they provide. Any information you get from these organizations is not meant to replace your health care provider’s medical advice.

Sarcoma organizations and websites

Sarcoma Alliance
www.sarcomaalliance.org
1-415-381-7236

Sarcoma Foundation of America
www.curesarcoma.org
1-301-253-8687

National Leiomyosarcoma Foundation
www.nlmsf.org
1-303-783-0924

National cancer resources

American Cancer Society
www.cancer.org
1-800-227-2345

National Cancer Institute
www.cancer.gov
1-800-4-CANCER (1-800-422-6237)

Association of Cancer Online Resources
www.acor.org
1-212-226-5525

CancerCare
www.cancercare.org
1-800-813-HOPE (1-800-813-4673)

Mobile and digital tools

Cancer.net Mobile
Available at www.cancer.net/app, this interactive tool helps keep track of questions to ask health care providers, among other features

Lotsa Helping Hands
Available at www.lotsahelpinghands.com, this tool helps with organizing aspects of your care, such as appointments, daily needs, etc.

Caregiver support

Family Caregiver Alliance
www.caregiver.org
1-800-445-8106

CancerCare
www.cancercare.org
1-800-813-HOPE (1-800-813-4673)

Cancer Support Community
www.cancersupportcommunity.org
1-888-793-9355

Next: Frequently Asked Questions

HCP Websites

Finding Support

VOTRIENT® (pazopanib) tablets

Create a circle of support

Find a support group

Ask for help

Communicating with your cancer care team

Always let your health care providers know:

Tips for caregivers: sharing your strength

Support and resources

Finding New Ways Forward

VOTRIENT^® (pazopanib) tablets