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Understanding Side Effects


Understanding Side Effects Understanding Side Effects

Understanding and tracking possible side effects of VOTRIENT

As with any medicine, you may experience some side effects with VOTRIENT® (pazopanib) tablets. But by learning more about the possible side effects, you can track the ones you may experience and work with your health care team to plan ahead for ways to manage them. Use this PDF to help keep track of any symptoms or side effects you may be experiencing.


Talk with your health care provider about any side effects that you may have.


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.


VOTRIENT can cause serious liver problems, including death. Your health care provider will do blood tests to check your liver before you start—and while you take—VOTRIENT.


Tell your health care provider right away if you get any of these signs of liver problems during treatment with VOTRIENT:

  • Yellowing of your skin or the whites of your eyes (jaundice)
  • Dark urine
  • Tiredness
  • Nausea or vomiting
  • Loss of appetite
  • Pain on the right side of your stomach area (abdomen)
  • Bruise easily


Your health care provider may need to prescribe a lower dose of VOTRIENT for you or tell you to stop taking VOTRIENT if you develop liver problems during treatment.

VOTRIENT may cause serious side effects including:


  • Irregular or fast heartbeat or fainting
  • Heart failure. This is a condition where your heart does not pump as well as it should and may cause you to have shortness of breath
  • Bleeding problems, which may be severe and cause death
  • Heart attack or stroke, which can happen and may cause death
    • Symptoms may include: chest pain or pressure, pain in your arms, back, neck or jaw, shortness of breath, numbness or weakness on one side of your body, trouble talking, headache, or dizziness
  • Blood clots, which may form in a vein, especially in your legs (deep vein thrombosis, or DVT). Pieces of a blood clot may travel to your lungs (pulmonary embolism). This may be life-threatening and cause death
  • Thrombotic microangiopathy (TMA), including thrombotic thrombocytopenia purpura and hemolytic uremic syndrome. TMA is a condition involving blood clots that can happen while taking VOTRIENT. TMA is accompanied by a decrease in red blood cells and cells that are involved in clotting. TMA may harm organs, such as the brain and kidneys
  • Tear in your stomach or intestinal wall (perforation) or an abnormal connection between 2 parts of your gastrointestinal tract (fistula). Symptoms may include: pain or swelling in your stomach area, vomiting blood, or black sticky stools
  • Lung problems. VOTRIENT may cause lung problems that may lead to death. Tell your health care provider right away if you get a cough that will not go away or shortness of breath
  • Reversible posterior leukoencephalopathy syndrome (RPLS). RPLS is a condition that can happen while taking VOTRIENT that may cause death. Symptoms may include: headaches, seizures, lack of energy, confusion, high blood pressure, loss of speech, blindness or changes in vision, and problems thinking
  • High blood pressure, including a sudden and severe rise in blood pressure, which may be life-threatening
    • These blood pressure increases usually happen in the first several months of treatment. Your blood pressure should be well controlled before you start taking VOTRIENT. Your health care provider should begin checking your blood pressure within 1 week of you starting VOTRIENT and often during treatment to make sure that your blood pressure is well controlled
    • Have someone call your health care provider or get medical help right away for you, if you have symptoms of a severe increase in blood pressure, including severe chest pain, severe headache, blurred vision, confusion, nausea and vomiting, severe anxiety, shortness of breath, or seizures, or you pass out (become unconscious)
  • Thyroid problems
  • Protein in your urine. If there is too much protein in your urine, your health care provider may tell you to stop taking VOTRIENT
  • Tumor lysis syndrome (TLS), a condition caused by a fast breakdown of cancer cells, which may cause death. Call your health care provider or get emergency medical help right away if you develop any of the following symptoms during treatment with VOTRIENT: irregular heartbeat, seizures, confusion, muscle cramps or spasms, or a decrease in urine output
  • Serious infections, which can cause death
    • Symptoms of an infection may include fever; cold symptoms, such as runny nose or sore throat that do not go away; flu symptoms, such as cough, tiredness, and body aches; pain when urinating; cuts, scrapes, or wounds that are red, warm, swollen, or painful
  • Collapsed lung (pneumothorax). A collapsed lung can happen with VOTRIENT. Air may get trapped in the space between your lung and chest wall. This may cause you to have shortness of breath


Call your health care provider right away if you experience any of the symptoms listed above.

The most common side effects in people who take VOTRIENT are


  • Diarrhea
  • Hair color changes
  • Nausea (feeling sick to your stomach) or vomiting
  • Loss of appetite

Tell your health care provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of VOTRIENT. For more information, ask your health care provider or pharmacist.