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VOTRIENT

IMPORTANT SAFETY INFORMATION, INCLUDING BOXED WARNING AND APPROVED USE

Before taking VOTRIENT, tell your health care provider if you have or had liver problems. Some people may develop liver damage while taking VOTRIENT. VOTRIENT can cause serious liver problems, including death. Your health care provider will do blood tests to check your liver before you start—and while you take—VOTRIENT. Tell your health care provider right away if you have yellow eyes or skin, dark urine, tiredness, nausea or vomiting, loss of appetite, pain in the right upper side of your stomach area, or if you bruise easily. Your health care provider may need to prescribe a lower dose of VOTRIENT for you or tell you to stop taking VOTRIENT if you develop liver problems during treatment.

VOTRIENT may cause irregular or fast heartbeat or fainting

VOTRIENT may cause heart failure, a condition where your heart does not pump as well as it should and which may result in shortness of breath

VOTRIENT may cause bleeding problems, which may be severe and cause death. Call your health care provider right away if you have unusual bleeding, bruising, or wounds that do not heal

Heart attack and stroke can happen with VOTRIENT and may cause death. Tell your health care provider if you have heart problems. Call your health care provider right away if you have chest pain or pressure, pain in your arms, back, neck or jaw, shortness of breath, numbness or weakness on one side of your body, trouble talking, headache, or dizziness

VOTRIENT may cause blood clots, which may form in a vein, especially in your legs. Pieces of a blood clot may travel to your lungs. This may be life-threatening and cause death. Call your health care provider right away if you have new chest pain, trouble breathing or sudden shortness of breath, leg pain, and swelling of the arms and hands, or legs and feet, or a cool or pale arm or leg

Thrombotic microangiopathy (TMA), including thrombotic thrombocytopenia purpura and hemolytic uremic syndrome, is a condition involving blood clots that can happen while taking VOTRIENT. TMA is accompanied by a decrease in red blood cells and cells that are involved in clotting. TMA may harm organs, such as the brain and kidneys

VOTRIENT may cause a tear (called a perforation) in the stomach or intestinal wall. Fatal perforations have occurred. VOTRIENT may also cause an abnormal connection between 2 parts of your gastrointestinal tract (called a fistula). Call your health care provider if you experience pain or swelling in the stomach area, vomiting blood, or black sticky stools

VOTRIENT may cause lung problems that may lead to death. Tell your health care provider right away if you develop a cough that will not go away or have shortness of breath

Reversible posterior leukoencephalopathy syndrome is a condition that can happen while taking VOTRIENT that may cause death. Symptoms may include headaches, seizures, lack of energy, confusion, high blood pressure, loss of speech, blindness or changes in vision, and problems thinking

High blood pressure can happen with VOTRIENT, including a sudden and severe rise in blood pressure which may be life-threatening. These blood pressure increases usually happen in the first several months of treatment. Blood pressure should be well controlled before starting VOTRIENT. Your health care provider should test your blood pressure within 1 week of starting treatment with VOTRIENT and should check it often during treatment. Get medical help right away if you have symptoms of a severe increase in blood pressure, such as severe chest pain, severe headache, blurred vision, confusion, nausea and vomiting, severe anxiety, shortness of breath, or seizures, or if you pass out (become unconscious)

VOTRIENT may cause thyroid problems. Your health care provider should test your thyroid function during treatment with VOTRIENT

VOTRIENT may affect wound healing. Tell your doctor if you had recent surgery (within the last 7 days) or are going to have surgery

VOTRIENT may cause you to have too much protein in your urine. Your health care provider will check you for this problem. If there is too much protein in your urine, your health care provider may tell you to stop taking VOTRIENT

Tumor lysis syndrome (TLS) is a condition that can happen during treatment with VOTRIENT, which may cause death. TLS is caused by a fast breakdown of cancer cells. Your health care provider may do blood tests to check you for TLS. Call your health care provider or get emergency medical help right away if you develop any of the following symptoms during treatment with VOTRIENT: irregular heartbeat, seizures, confusion, muscle cramps or spasms, or a decrease in urine output

Serious infections can happen with VOTRIENT and can cause death. Call your health care provider if you experience fever; cold symptoms, such as runny nose or a sore throat that does not go away; flu symptoms, such as cough, feeling tired, and body aches; pain when urinating; or cuts, scrapes, or wounds that are red, warm, swollen, or painful

When used in combination with some other anticancer therapies, VOTRIENT has caused increased toxicity and even death. Tell your health care provider about all of the medicines you are taking, including other anticancer therapies

FEMALES OF REPRODUCTIVE/CHILDBEARING POTENTIAL. VOTRIENT can harm your unborn baby (cause birth defects or potential loss of pregnancy). You should not become pregnant while you are taking VOTRIENT. You should use effective birth control during treatment with VOTRIENT and for at least 2 weeks after your final dose of VOTRIENT. Talk to your health care provider about the types of birth control that may be right for you during this time

MALES OF REPRODUCTIVE POTENTIAL. Talk to your doctor if you are a male, even if you have had a vasectomy, and you are with a sexual partner who is pregnant, thinks that she may be pregnant, or who could become pregnant (including those who use other forms of birth control). You should use condoms during sexual intercourse during treatment with VOTRIENT and for at least 2 weeks after your last dose with VOTRIENT

BREASTFEEDING. It is not known if VOTRIENT passes into your breast milk. Do not breastfeed during treatment with VOTRIENT and for 2 weeks after the final dose

A collapsed lung can happen with VOTRIENT (called pneumothorax). This may cause shortness of breath. Call your health care provider right away if you experience shortness of breath

The most common side effects in people with advanced renal cell cancer who take VOTRIENT include:

- Diarrhea
- Hair color changes
- Nausea (feeling sick to your stomach) or vomiting
- Loss of appetite

Tell your health care provider right away if you have any side effects.

VOTRIENT may affect the way other medicines work, and other medicines may affect how VOTRIENT works. Tell your health care provider about all the medicines you take, including prescription and nonprescription medicines and herbal and dietary supplements.

Do not eat grapefruit or drink grapefruit juice during treatment with VOTRIENT, because it may affect how VOTRIENT works.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information, including Boxed WARNING, and Medication Guide.

Approved Use:

VOTRIENT^® (pazopanib) tablets is a prescription medicine used to treat people with advanced renal cell cancer (RCC).

It is not known if VOTRIENT is safe and effective in children under 18 years of age.

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Prescribing Info

including Med Guide

Patient Support Line

1-888-669-6682

M-F 8:30 AM-5:00 PM ET

Patient Support Line

1-888-669-6682

M-F 8:30 AM-5:00 PM ET

Important Safety Information, including Boxed WARNING:

Before taking VOTRIENT, tell your health care provider if you have or had liver problems. Some people may develop liver damage while taking VOTRIENT....

Approved Use:

VOTRIENT^® (pazopanib) tablets is a prescription medicine used to treat people with advanced renal cell cancer (RCC).

It is not known if VOTRIENT is safe and effective in children under 18 years of age.

Important Safety Information, including Boxed WARNING:

VOTRIENT may cause irregular or fast heartbeat or fainting

VOTRIENT may cause heart failure, a condition where your heart does not pump as well as it should and which may result in shortness of breath

VOTRIENT may cause bleeding problems, which may be severe and cause death. Call your health care provider right away if you have unusual bleeding, bruising, or wounds that do not heal

Heart attack and stroke can happen with VOTRIENT and may cause death. Tell your health care provider if you have heart problems. Call your health care provider right away if you have chest pain or pressure, pain in your arms, back, neck or jaw, shortness of breath, numbness or weakness on one side of your body, trouble talking, headache, or dizziness

VOTRIENT may cause blood clots, which may form in a vein, especially in your legs. Pieces of a blood clot may travel to your lungs. This may be life-threatening and cause death. Call your health care provider right away if you have new chest pain, trouble breathing or sudden shortness of breath, leg pain, and swelling of the arms and hands, or legs and feet, or a cool or pale arm or leg

Thrombotic microangiopathy (TMA), including thrombotic thrombocytopenia purpura and hemolytic uremic syndrome, is a condition involving blood clots that can happen while taking VOTRIENT. TMA is accompanied by a decrease in red blood cells and cells that are involved in clotting. TMA may harm organs, such as the brain and kidneys

VOTRIENT may cause a tear (called a perforation) in the stomach or intestinal wall. Fatal perforations have occurred. VOTRIENT may also cause an abnormal connection between 2 parts of your gastrointestinal tract (called a fistula). Call your health care provider if you experience pain or swelling in the stomach area, vomiting blood, or black sticky stools

VOTRIENT may cause lung problems that may lead to death. Tell your health care provider right away if you develop a cough that will not go away or have shortness of breath

Reversible posterior leukoencephalopathy syndrome is a condition that can happen while taking VOTRIENT that may cause death. Symptoms may include headaches, seizures, lack of energy, confusion, high blood pressure, loss of speech, blindness or changes in vision, and problems thinking

High blood pressure can happen with VOTRIENT, including a sudden and severe rise in blood pressure which may be life-threatening. These blood pressure increases usually happen in the first several months of treatment. Blood pressure should be well controlled before starting VOTRIENT. Your health care provider should test your blood pressure within 1 week of starting treatment with VOTRIENT and should check it often during treatment. Get medical help right away if you have symptoms of a severe increase in blood pressure, such as severe chest pain, severe headache, blurred vision, confusion, nausea and vomiting, severe anxiety, shortness of breath, or seizures, or if you pass out (become unconscious)

VOTRIENT may cause thyroid problems. Your health care provider should test your thyroid function during treatment with VOTRIENT

VOTRIENT may affect wound healing. Tell your doctor if you had recent surgery (within the last 7 days) or are going to have surgery

VOTRIENT may cause you to have too much protein in your urine. Your health care provider will check you for this problem. If there is too much protein in your urine, your health care provider may tell you to stop taking VOTRIENT

Tumor lysis syndrome (TLS) is a condition that can happen during treatment with VOTRIENT, which may cause death. TLS is caused by a fast breakdown of cancer cells. Your health care provider may do blood tests to check you for TLS. Call your health care provider or get emergency medical help right away if you develop any of the following symptoms during treatment with VOTRIENT: irregular heartbeat, seizures, confusion, muscle cramps or spasms, or a decrease in urine output

Serious infections can happen with VOTRIENT and can cause death. Call your health care provider if you experience fever; cold symptoms, such as runny nose or a sore throat that does not go away; flu symptoms, such as cough, feeling tired, and body aches; pain when urinating; or cuts, scrapes, or wounds that are red, warm, swollen, or painful

When used in combination with some other anticancer therapies, VOTRIENT has caused increased toxicity and even death. Tell your health care provider about all of the medicines you are taking, including other anticancer therapies

FEMALES OF REPRODUCTIVE/CHILDBEARING POTENTIAL. VOTRIENT can harm your unborn baby (cause birth defects or potential loss of pregnancy). You should not become pregnant while you are taking VOTRIENT. You should use effective birth control during treatment with VOTRIENT and for at least 2 weeks after your final dose of VOTRIENT. Talk to your health care provider about the types of birth control that may be right for you during this time

MALES OF REPRODUCTIVE POTENTIAL. Talk to your doctor if you are a male, even if you have had a vasectomy, and you are with a sexual partner who is pregnant, thinks that she may be pregnant, or who could become pregnant (including those who use other forms of birth control). You should use condoms during sexual intercourse during treatment with VOTRIENT and for at least 2 weeks after your last dose with VOTRIENT

BREASTFEEDING. It is not known if VOTRIENT passes into your breast milk. Do not breastfeed during treatment with VOTRIENT and for 2 weeks after the final dose

A collapsed lung can happen with VOTRIENT (called pneumothorax). This may cause shortness of breath. Call your health care provider right away if you experience shortness of breath

The most common side effects in people with advanced renal cell cancer who take VOTRIENT include:

- Diarrhea
- Hair color changes
- Nausea (feeling sick to your stomach) or vomiting
- Loss of appetite

Tell your health care provider right away if you have any side effects.

Do not eat grapefruit or drink grapefruit juice during treatment with VOTRIENT, because it may affect how VOTRIENT works.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information, including Boxed WARNING, and Medication Guide.

Approved Use:

VOTRIENT^® (pazopanib) tablets is a prescription medicine used to treat people with advanced renal cell cancer (RCC).

It is not known if VOTRIENT is safe and effective in children under 18 years of age.

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Resources for you

These tools and resources were designed specifically for people taking or considering VOTRIENT^® (pazopanib) tablets. Keep these resources on hand so you can use them any time you need. The goal is to help you get the most out of your care.

Learning About VOTRIENT

VOTRIENT Brochure

Learn even more about treating advanced renal cell cancer with VOTRIENT.

Download PDF

Planning for Appointments

Prepare for Your Appointments

Plan ahead for your conversation with questions and information to help you get the most out of your visit.

Download PDF

Keeping Track of Symptoms

Manage Your Day

Revisit strategies you used to manage any symptoms or side effects, and share what worked with your health care provider.

Download PDF

Keeping Track of Tests

Track Your Tests

Keep a record of your tests, your results, and next steps you and your health care provider decide on.

Download PDF

Getting Support

My VOTRIENT Quick Guide

Work with your health care team to determine your daily routine for taking VOTRIENT. Fill out this sheet as a reference and reminder.

Download PDF

Personal Contacts

Create a list of who you may call on for support or help so you have all of this information in one place.

Download PDF

Important Information

Keep your health care, personal, and emergency contact information all in one place.

Download PDF

Resources for caregivers

Navigating the treatment journey is a team effort. As a caregiver, you also need support to help you along the way. Use the resources below, and come back to them any time you need.

Caregiver Conversation Guide

Use the Caregiver Conversation Guide to help you have open, honest talks with your health care team.

Download PDF

Build Your Caregiver Circle

Download this worksheet to find more support for you as a caregiver and to help you create time for the things you enjoy.

Download PDF

Additional tools and resources

These organizations offer information other patients have found helpful. You may also find they’re useful as you learn more about living with advanced renal cell cancer (advanced kidney cancer). These resources are external to Novartis. Novartis is neither affiliated with nor endorses any of these organizations and is not responsible for the information they provide. Information from these organizations is not meant to replace your health care provider’s medical advice.

American Cancer Society (ACS)

Explore this site to find out more about a national advocacy group offering information, support, and ways to get involved, as well as local resources.