For US residents only.
It’s important to understand what metastatic renal cell carcinoma (advanced kidney cancer) means and how treatment works in your body. Use this page to find answers to frequently asked questions about . Use the glossary included to help you understand any new terms you may hear from your health care team.
Take a moment to read the Medication Guide before you start taking VOTRIENT and each time you get a refill. There may be new information. The Medication Guide and these frequently asked questions about VOTRIENT do not take the place of talking with your health care provider about metastatic renal cell carcinoma (advanced kidney cancer) and treatment with VOTRIENT.
As your health care provider may have told you, VOTRIENT is a prescription medicine used to treat metastatic renal cell carcinoma. It is not known if VOTRIENT is safe or effective in children under 18 years of age. Find out more about how VOTRIENT may help.
Every medicine comes with a list of possible side effects that you may experience. It’s important to be aware of these things ahead of time so that you can let your health care provider know if you have any concerns. Here is the most important information to know about VOTRIENT.
VOTRIENT can cause serious liver problems including death. Your health care provider will do blood tests to check your liver before you start and while you take VOTRIENT.
Tell your health care provider right away if you get any of these signs of liver problems during treatment with VOTRIENT:
Your health care provider may need to prescribe a lower dose of VOTRIENT for you or tell you to stop taking VOTRIENT if you develop liver problems during treatment. Use Your Weekly Symptom Tracker (downloadable PDF) to help you notice any patterns and share with your health care team so they can help you plan ahead.
Before you start any new medicine, it’s important to discuss your medical history and any medicines that you have taken or are currently taking. That way, your health care provider can be sure to monitor you appropriately so you can get the most out of your treatment. Take a look at the lists below, and make note of anything you may need to discuss at your next appointment.
Before you take VOTRIENT, tell your health care provider if you
Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. VOTRIENT may affect the way other medicines work, and other medicines may affect how VOTRIENT works.
Especially tell your health care provider if you
Ask your health care provider if you are not sure if your medicine is one that is listed above. Also let your health care provider know about any other medical conditions you may have. Know the medicines you take. Keep a list of them, and show it to your health care provider and pharmacist when you get a new medicine.
Learn more about potential side effects so you can work with your health care team to plan ahead.
As you begin a new medicine, it can be helpful to consider ways to create a routine that works for you. Use the calendar to see how different times may fit into your schedule. Keep these things in mind while on treatment with VOTRIENT:
It may take a little adjusting to find the best time for you to take VOTRIENT, but there are resources and information on this site designed to help you get there.
If you miss a dose, take it as soon as you remember. Do not take it if it is close (within 12 hours) to your next dose. Just take the next dose at your regular time. Do not take more than 1 dose of VOTRIENT at a time. Call your health care provider if you have any questions.
Keep in mind that everyone experiences side effects differently. VOTRIENT may cause serious side effects, including
Call your health care provider right away if you have any of the symptoms listed above.
The most common side effects in people who take VOTRIENT include
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of VOTRIENT. Learn more about potential side effects to help plan ahead. For more information, ask your health care provider or pharmacist.
When starting a new medicine, it’s helpful to know how it works so you can know what to expect. As you talk with your health care provider about treating metastatic renal cell carcinoma (advanced kidney cancer), you’ve likely learned that it may be controlled with VOTRIENT.
VOTRIENT works to prevent the growth of new blood vessels to the tumor and may shrink or slow the growth of the cancer by stopping a protein called vascular endothelial growth factor or VEGF (vehj eff). VEGF is important for the growth of blood vessels to supply nutrients to the tumor cell. It is important to note that VOTRIENT may also harm healthy cells. Learn more about how VOTRIENT works.
Treatments for metastatic renal cell carcinoma (advanced kidney cancer) work differently for everybody. Your health care provider will perform tests and regularly monitor your body's functions. He or she can help let you know if VOTRIENT is helping you during your appointments, so be sure to ask any questions you may have. Learn more about how VOTRIENT works.
Store VOTRIENT at room temperature between 68oF and 77oF (20oC to 25oC). Get more information and resources for taking VOTRIENT.
Keep VOTRIENT and all medicines out of the reach of children.
Yes. It is best to avoid grapefruit and grapefruit juice while on VOTRIENT, because it may affect how the medicine works in your body. Ask your health care provider about any additional foods you should avoid. Learn more about how to take VOTRIENT.
Active ingredient: pazopanib.
Inactive ingredients: Tablet core: Magnesium stearate, microcrystalline cellulose, povidone, sodium starch glycolate. Coating: Gray film-coat: Hypromellose, iron oxide black, macrogol/polyethylene glycol 400 (PEG 400), polysorbate 80, titanium dioxide.
As your health care provider monitors you while you’re on VOTRIENT, he or she will be able to better estimate how long you may need to take VOTRIENT. Treatments for metastatic renal cell carcinoma (advanced kidney cancer) work differently for everybody. Learn more about how VOTRIENT works. You can also download the Conversation Guide (downloadable PDF) to help you get ideas of what you may want to discuss at your next appointment.
Use this glossary any time you need to get a better understanding of some of the standard terms used. You can also ask your health care provider to clarify any of these terms during your appointments.
A biopsy is the removal of cells or tissues so they can be viewed under a microscope to check for signs of cancer.
A CT scan is a procedure that creates a series of detailed images from different angles of areas inside the body.
Fatigue is extreme tiredness.
Hematuria is blood in the urine.
Hypertension is another term for high blood pressure.
Kidney cancer occurs when cells start to grow out of control in the kidney.
A lesion is an area in an organ or tissue that has been damaged through injury or disease.
This procedure uses a magnet, radio waves, and a computer to create detailed images of areas inside the body.
Sometimes kidney cancer cells spread to lymph nodes or other parts of the body. Even though the cancer cells have spread to other parts of the body, your health care provider will still call it kidney cancer, because that is where the cancer cells started.
A nephrectomy is the partial or full surgical removal of a kidney.
In some cases, a medicine that was working to treat a patient’s cancer stops working. This is called treatment resistance. When this happens, your health care provider will work with you and let you know of other treatment options to be considered.
VEGF is a protein that is important in the growth of blood vessels to supply nutrients to the tumor cell.
VOTRIENT is used to treat adults with metastatic renal cell carcinoma, a form of kidney cancer. VOTRIENT may shrink or slow the growth of kidney cancer for a period of time. VOTRIENT is not a cure for kidney cancer.