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How Treatment May Help

VOTRIENT

How Treatment May Help How Treatment May Help

Understanding how renal cell carcinoma treatment may help

You are already taking steps toward managing metastatic renal cell carcinoma (advanced kidney cancer) by learning more about treating it. When starting a new medicine, it’s helpful to know how it works so you can know what to expect. As you talk with your team about renal cell carcinoma treatment options for metastatic renal cell carcinoma, together you may have made a decision to begin treatment with VOTRIENT® (pazopanib) tablets.

 

VOTRIENT works to prevent the growth of new blood vessels to the tumor and may shrink or slow the growth of the cancer by stopping a protein called vascular endothelial growth factor or VEGF (vehj eff). VEGF is important for the growth of blood vessels to supply nutrients to the tumor cells. Note that VOTRIENT may also harm healthy cells.

How does VOTRIENT work?

To get a better understanding of the way VOTRIENT may work, review the images below and talk with your health care team.

 

Without VOTRIENT
Kidney cancer happens in your body when cells start to grow out of control in the kidney. Sometimes these kidney cancer cells spread to lymph nodes or other parts of the body. Even though the cancer cells have spread to other parts of the body, your health care provider will still call it kidney cancer because that’s where the cancer cells started.  

With VOTRIENT
VOTRIENT may shrink or slow the growth of the cancer by interfering with the function of a protein called vascular endothelial growth factor. VEGF is important for the growth of blood vessels, which supply nutrients to the tumor cells. Note that VOTRIENT may also harm healthy cells.

Partner with your health care provider to learn more about VOTRIENT as a first-line therapy and whether it’s right for you. Here are some points to keep in mind as you discuss VOTRIENT:

 

  • VOTRIENT is used to treat adults with metastatic renal cell carcinoma, a form of kidney cancer
  • VOTRIENT may shrink or slow the growth of kidney cancer for a period of time
  • VOTRIENT is not a cure for kidney cancer
  • VOTRIENT is not a chemotherapy drug

 

Topics to discuss with your health care provider before starting VOTRIENT

It’s important to talk with your health care provider about certain medical conditions you have had and which medicines you are taking, because these may impact how VOTRIENT works in your body. Here are a few things to mention to your health care provider before you start taking VOTRIENT.

 

  • What’s your medical history?
  • Talk to your health care provider if you have or have had any of the following:

 

    • Liver problems. You may need a lower dose of VOTRIENT or your health care provider may prescribe a different medicine to treat your metastatic renal cell carcinoma
    • High blood pressure
    • Heart problems or an irregular heartbeat, including QT prolongation
    • A history of stroke
    • Headaches, seizures, or vision problems
    • Coughed up blood in the last 6 months
    • Bleeding of your stomach or intestines in the last 6 months
    • A history of a tear (perforation) in your stomach or intestine, or an abnormal connection between 2 parts of your gastrointestinal tract (fistula)
    • Blood clots in a vein or a lung
    • Thyroid problems
    • Recent surgery (within the last 7 days) or are going to have surgery

 

Read a complete list of medical history items to discuss with your health care provider when starting VOTRIENT, and share it at your next appointment.